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Clark International Airport ( IATA: CRK, ICAO: RPLC ), known as Diosdado Macapagal International Airport from 2003 to 2014, is an international airport covering portions of the cities of Angeles and Mabalacat within the Clark Freeport Zone in the province of Pampanga, Philippines. It is located 80 kilometers (50 mi) [6] northwest of Manila.
Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction.
Active (GTP-bound) RhoG recruits the ELMO/Dock180 complex to the plasma membrane thereby bringing Dock180 into contact with its substrate, Rac. In tumour cells DOCK180 is regulated by a complex containing Crk and p130Cas which is in turn regulated by cooperative signalling by β 3 -containing integrin complexes and the membrane-bound protein uPAR .
ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells.
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