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Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and ...
For example, in 2013, Fu et al. reported that by truncating the gRNA from <20 bp in length to 17 or 18 bp the target specificity of the nuclease increased up to 5,000 fold and mismatch occurrences above 3 bases rarely, if ever occurred.
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The Pareto principle may apply to fundraising, i.e. 20% of the donors contributing towards 80% of the total The Pareto principle (also known as the 80/20 rule , the law of the vital few and the principle of factor sparsity [1] [2] ) states that for many outcomes, roughly 80% of consequences come from 20% of causes (the "vital few").
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Products. Clothing, shoes, accessories, branding. Owner. LVMH. Website. www .off---white .com. Off-White (stylized as Off-White c/o Virgil Abloh) is an Italian luxury fashion house founded by American designer Virgil Abloh. The company was incorporated in Milan in 2013. [2] [3]