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Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of the antimineralocorticoid and ...
The company is one of the largest American-owned private employers in the United States. The corporation was founded in Minneapolis by businessman George Dayton in 1902, and developed through the years via expansion and acquisitions. Target, the company's first discount store and eventual namesake, was opened in 1962.
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Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats ( CRISPR )- Cas9, transcription activator-like effector nucleases ( TALEN ), meganucleases, and zinc finger nucleases (ZFN). [1]
The Pareto principle may apply to fundraising, i.e. 20% of the donors contributing towards 80% of the total The Pareto principle (also known as the 80/20 rule , the law of the vital few and the principle of factor sparsity [1] [2] ) states that for many outcomes, roughly 80% of consequences come from 20% of causes (the "vital few").
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